DXP reductoisomerase

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1-deoxy-D-xylulose-5-phosphate reductoisomerase
PDB 1q0q EBI.jpg
crystal structure of DXR in complex with the substrate 1-deoxy-D-xylulose 5-phosphate
Identifiers
SymbolDXP_reductoisom
PfamPF02670
Pfam clanCL0063
InterProIPR013512
SCOPe1onn / SUPFAM
DXP reductoisomerase
Identifiers
EC number1.1.1.267
CAS number210756-42-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

DXP reductoisomerase (1-deoxy-D-xylulose 5-phosphate reductoisomerase or DXR) is an enzyme that interconverts 1-deoxy-D-xylulose 5-phosphate (DXP) and 2-C-methyl-D-erythritol 4-phosphate (MEP).[1]

It is classified under EC 1.1.1.267. It is normally abbreviated DXR, but it is sometimes named IspC, as the product of the ispC gene.

DXR is part of the MEP pathway (nonmevalonate pathway) of isoprenoid precursor biosynthesis. DXR is inhibited by fosmidomycin.

This enzyme is required for terpenoid biosynthesis in some organisms, since it is a key enzyme on the MEP pathway for the production of the isoprenoid precursors IPP and DMAPP.[1] In Arabidopsis thaliana 1-deoxy-D-xylulose 5-phosphate reductoisomerase is the first committed enzyme of the MEP pathway for isoprenoid precursor biosynthesis. The enzyme requires Mn2+, Co2+ or Mg2+ for activity, with Mn2+ being most effective.

References[edit]

  1. ^ a b Takahashi S, Kuzuyama T, Watanabe H, Seto H (August 1998). "A 1-deoxy-D-xylulose-5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in the non-mevalonate pathway for terpenoid biosynthesis". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9879–84. doi:10.1073/pnas.95.17.9879. PMC 21430. PMID 9707569.

External links[edit]

This article incorporates text from the public domain Pfam and InterPro: IPR013512
This article incorporates text from the public domain Pfam and InterPro: IPR013644