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Protein ELK4 PDB 1bc7.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesELK4, SAP1, ETS transcription factor, ETS transcription factor ELK4
External IDsMGI: 102853 HomoloGene: 1492 GeneCards: ELK4
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for ELK4
Genomic location for ELK4
Band1q32.1Start205,597,556 bp[1]
End205,631,962 bp[1]
RNA expression pattern
PBB GE ELK4 206919 at fs.png

PBB GE ELK4 205994 at fs.png

PBB GE ELK4 214831 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 1: 205.6 – 205.63 MbChr 1: 132.01 – 132.03 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

ETS domain-containing protein Elk-4 is a protein that in humans is encoded by the ELK4 gene.[5][6][7]


This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene.[7]


ELK4 has been shown to interact with:


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158711 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026436 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Shipley J, Sheer D, Dalton S, Treisman R, Patel K (Mar 1995). "Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively". Genomics. 23 (3): 710–1. doi:10.1006/geno.1994.1564. PMID 7851904.
  6. ^ Giovane A, Sobieszczuk P, Mignon C, Mattei MG, Wasylyk B (Mar 1996). "Locations of the ets subfamily members net, elk1, and sap1 (ELK3, ELK1, and ELK4) on three homologous regions of the mouse and human genomes". Genomics. 29 (3): 769–72. doi:10.1006/geno.1995.9938. PMID 8575773.
  7. ^ a b "Entrez Gene: ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)".
  8. ^ Chai Y, Chipitsyna G, Cui J, Liao B, Liu S, Aysola K, Yezdani M, Reddy ES, Rao VN (Mar 2001). "c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells". Oncogene. 20 (11): 1357–67. doi:10.1038/sj.onc.1204256. PMID 11313879.
  9. ^ Hassler M, Richmond TJ (Jun 2001). "The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex". EMBO J. 20 (12): 3018–28. doi:10.1093/emboj/20.12.3018. PMC 150215. PMID 11406578.
  10. ^ Zhu C, Johansen FE, Prywes R (Sep 1997). "Interaction of ATF6 and serum response factor". Mol. Cell. Biol. 17 (9): 4957–66. PMC 232347. PMID 9271374.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.