EPHA7

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EPHA7
Protein EPHA7 PDB 2REI.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEPHA7, EHK-3, EHK3, EK11, HEK11, EPH receptor A7
External IDsOMIM: 602190 MGI: 95276 HomoloGene: 20935 GeneCards: EPHA7
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for EPHA7
Genomic location for EPHA7
Band6q16.1Start93,240,020 bp[1]
End93,419,559 bp[1]
RNA expression pattern
PBB GE EPHA7 206852 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001288629
NM_001288630
NM_004440

NM_001122889
NM_001290434
NM_010141

RefSeq (protein)

NP_001275558
NP_001275559
NP_004431

NP_001116361
NP_001277363
NP_034271

Location (UCSC)Chr 6: 93.24 – 93.42 MbChr 4: 28.81 – 28.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ephrin type-A receptor 7 is a protein that in humans is encoded by the EPHA7 gene.[5][6]

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135333 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028289 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ephnomenclaturecommittee (Sep 1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell. 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020.
  6. ^ a b "Entrez Gene: EPHA7 EPH receptor A7".

Further reading[edit]