EPH receptor B1

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Protein EPHB1 PDB 2djs.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesEPHB1, Ephb1, 9330129L11, AW488255, C130099E04Rik, Cek6, ENSMUSG00000074119, Elk, Elkh, Hek6, Net, EPHT2, EPH receptor B1, ELK, NET
External IDsOMIM: 600600 MGI: 1096337 HomoloGene: 20936 GeneCards: EPHB1
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for EPHB1
Genomic location for EPHB1
Band3q22.2Start134,597,801 bp[1]
End135,260,467 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 3: 134.6 – 135.26 MbChr 9: 101.92 – 102.35 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Ephrin type-B receptor 1 is a protein that in humans is encoded by the EPHB1 gene.[5][6]


Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.[6]


EPH receptor B1 has been shown to interact with:


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154928 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032537 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tang XX, Biegel JA, Nycum LM, Yoshioka A, Brodeur GM, Pleasure DE, Ikegaki N (1995). "cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein-tyrosine kinase gene preferentially expressed in brain". Genomics. 29 (2): 426–37. doi:10.1006/geno.1995.9985. PMID 8666391.
  6. ^ a b "Entrez Gene: EPHB1 EPH receptor B1".
  7. ^ Stein E, Lane AA, Cerretti DP, Schoecklmann HO, Schroff AD, Van Etten RL, Daniel TO (Mar 1998). "Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses". Genes Dev. 12 (5): 667–78. doi:10.1101/gad.12.5.667. PMC 316584. PMID 9499402.
  8. ^ Han DC, Shen TL, Miao H, Wang B, Guan JL (Nov 2002). "EphB1 associates with Grb7 and regulates cell migration". J. Biol. Chem. 277 (47): 45655–61. doi:10.1074/jbc.M203165200. PMID 12223469.
  9. ^ Stein E, Huynh-Do U, Lane AA, Cerretti DP, Daniel TO (Jan 1998). "Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase". J. Biol. Chem. 273 (3): 1303–8. doi:10.1074/jbc.273.3.1303. PMID 9430661.
  10. ^ Williams, SE; Mann, F; Erskine, L (2003). "Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm". Neuron. 39 (6): 919–935. doi:10.1016/j.neuron.2003.08.017.

Further reading[edit]