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AliasesERV3-1, ERV-R, ERV3, ERVR, HERV-R, HERVR, envR, endogenous retrovirus group 3 member 1, endogenous retrovirus group 3 member 1, envelope
External IDsOMIM: 131170 HomoloGene: 128310 GeneCards: ERV3-1
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for ERV3-1
Genomic location for ERV3-1
Band7q11.21Start64,990,356 bp[1]
End65,006,743 bp[1]
RNA expression pattern
PBB GE ERV3 gnf1h04728 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 7: 64.99 – 65.01 Mbn/a
PubMed search[2]n/a
View/Edit Human

HERV-R_7q21.2 provirus ancestral Env polyprotein is a protein that in humans is encoded by the ERV3 gene.[3][4][5]


The human genome includes many retroelements including the human endogenous retroviruses (HERVs). ERV3, one of the most studied HERVs, is thought to have integrated 30 to 40 million years ago and is present in higher primates with the exception of gorillas. Taken together, the observation of genome conservation, the detection of transcript expression, and the presence of conserved ORFs is circumstantial evidence for a functional role. A functional role is also suggested by the observation that downregulation of ERV3 is reported in choriocarcinoma.[5]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000213462 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Kato N, Shimotohno K, VanLeeuwen D, Cohen M (August 1990). "Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Krüppel". Molecular and Cellular Biology. 10 (8): 4401–5. doi:10.1128/mcb.10.8.4401. PMC 361000. PMID 2115127.
  4. ^ O'Connell C, O'Brien S, Nash WG, Cohen M (October 1984). "ERV3, a full-length human endogenous provirus: chromosomal localization and evolutionary relationships". Virology. 138 (2): 225–35. doi:10.1016/0042-6822(84)90347-7. PMID 6495650.
  5. ^ a b "Entrez Gene: ERV3 endogenous retroviral sequence 3 (includes zinc finger protein H-plk/HPF9)".

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.