Estradiol hemisuccinate

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Estradiol hemisuccinate
Estradiol succinate.svg
Clinical data
Trade namesEutocol, Hosterona (with progesterone)
Other namesEstradiol succinate; Estradiol 17β-hemisuccinate; Estradiol 17β-succinate
Routes of
By mouth, intramuscular injection
Drug classEstrogen; Estrogen ester
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.163.857 Edit this at Wikidata
Chemical and physical data
Molar mass372.46 g/mol g·mol−1
3D model (JSmol)

Estradiol hemisuccinate (brand name Eutocol), or simply estradiol succinate, also known as estradiol 17β-hemisuccinate, is an estrogen medication and an estrogen ester – specifically, the hemisuccinate ester of estradiol.[1] It is used as a component of hormone replacement therapy for menopause.[2] Like other estrogens, estradiol hemisuccinate has been found to have beneficial effects on the skin, with improvement of skin thickness observed.[3][4]

Estradiol hemisuccinate is also a component of estradiol hemisuccinate/progesterone (brand name Hosterona), an injectable preparation used to induce withdrawal bleeding in women with amenorrhea.[5][6][7]

See also[edit]


  1. ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 897. ISBN 978-1-4757-2085-3.
  2. ^ Miranda A. Farage; Kenneth W. Miller; Howard I. Maibach (2 December 2009). Textbook of Aging Skin. Springer Science & Business Media. pp. 362–. ISBN 978-3-540-89655-5.
  3. ^ Thompson, Zack; Maibach, Howard I. (2010). "Biological Effects of Estrogen on Skin": 361–367. doi:10.1007/978-3-540-89656-2_35. Cite journal requires |journal= (help)
  4. ^ Maheux R, Naud F, Rioux M, Grenier R, Lemay A, Guy J, Langevin M (1994). "A randomized, double-blind, placebo-controlled study on the effect of conjugated estrogens on skin thickness". Am. J. Obstet. Gynecol. 170 (2): 642–9. doi:10.1016/s0002-9378(94)70242-x. PMID 8116726.
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