FMO5

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FMO5
Identifiers
AliasesFMO5, flavin containing monooxygenase 5, flavin containing dimethylaniline monoxygenase 5
External IDsOMIM: 603957 MGI: 1310004 HomoloGene: 68185 GeneCards: FMO5
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for FMO5
Genomic location for FMO5
Band1q21.1Start147,175,351 bp[1]
End147,243,050 bp[1]
RNA expression pattern
PBB GE FMO5 205776 at fs.png

PBB GE FMO5 215300 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001144829
NM_001144830
NM_001461

NM_001161763
NM_001161765
NM_010232
NM_001355119

RefSeq (protein)

NP_001138301
NP_001138302
NP_001452

NP_001155235
NP_001155237
NP_034362
NP_001342048

Location (UCSC)Chr 1: 147.18 – 147.24 MbChr 3: 97.63 – 97.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dimethylaniline monooxygenase [N-oxide-forming] 5 is an enzyme that in humans is encoded by the FMO5 gene.[5][6][7]

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.[7]

Related gene problems[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131781 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028088 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ McCombie RR, Dolphin CT, Povey S, Phillips IR, Shephard EA (Sep 1996). "Localization of human flavin-containing monooxygenase genes FMO2 and FMO5 to chromosome 1q". Genomics. 34 (3): 426–9. doi:10.1006/geno.1996.0308. PMID 8786146.
  6. ^ Gelb BD, Zhang J, Cotter PD, Gershin IF, Desnick RJ (Apr 1997). "Physical mapping of the human connexin 40 (GJA5), flavin-containing monooxygenase 5, and natriuretic peptide receptor a genes on 1q21". Genomics. 39 (3): 409–11. doi:10.1006/geno.1996.4516. PMID 9119381.
  7. ^ a b "Entrez Gene: FMO5 flavin containing monooxygenase 5".

Further reading[edit]