From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
AliasesGABRB1, gamma-aminobutyric acid type A receptor beta1 subunit, EIEE45
External IDsOMIM: 137190 MGI: 95619 HomoloGene: 20221 GeneCards: GABRB1
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for GABRB1
Genomic location for GABRB1
Band4p12Start46,993,723 bp[1]
End47,426,444 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 4: 46.99 – 47.43 MbChr 5: 71.66 – 72.15 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Gamma-aminobutyric acid receptor subunit beta-1 is a protein that in humans is encoded by the GABRB1 gene.[5]


The gamma-aminobutyric acid A receptor (GABAA receptor) is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABAA receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia.[5]

Clinical significance[edit]

Mice bearing mutant copies of this gene have been shown to be vulnerable to binge drinking of alcohol.[6]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163288 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029212 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1".
  6. ^ Anstee QM, Knapp S, Maguire EP, Hosie AM, Thomas P, Mortensen M, Bhome R, Martinez A, Walker SE, Dixon CI, Ruparelia K, Montagnese S, Kuo YT, Herlihy A, Bell JD, Robinson I, Guerrini I, McQuillin A, Fisher EM, Ungless MA, Gurling HM, Morgan MY, Brown SD, Stephens DN, Belelli D, Lambert JJ, Smart TG, Thomas HC (November 2013). "Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition". Nat Commun. 4: 2816. doi:10.1038/ncomms3816. PMC 3843143. PMID 24281383.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.