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Available structures
PDBOrtholog search: PDBe RCSB
AliasesGTF2H4, general transcription factor IIH, polypeptide 4, 52kDa, P52, TFB2, TFIIH, general transcription factor IIH subunit 4
External IDsMGI: 1338799 HomoloGene: 7090 GeneCards: GTF2H4
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for GTF2H4
Genomic location for GTF2H4
Band6p21.33Start30,908,207 bp[1]
End30,914,106 bp[1]
RNA expression pattern
PBB GE GTF2H4 203577 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 6: 30.91 – 30.91 MbChr 17: 35.67 – 35.67 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

General transcription factor IIH subunit 4 is a protein that in humans is encoded by the GTF2H4 gene.[5][6]


GTF2H4 has been shown to interact with:

See also[edit]


  1. ^ a b c ENSG00000236895, ENSG00000233149, ENSG00000221974, ENSG00000213780, ENSG00000226384 GRCh38: Ensembl release 89: ENSG00000234370, ENSG00000236895, ENSG00000233149, ENSG00000221974, ENSG00000213780, ENSG00000226384 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001524 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b Marinoni JC, Roy R, Vermeulen W, Miniou P, Lutz Y, Weeda G, Seroz T, Gomez DM, Hoeijmakers JH, Egly JM (Apr 1997). "Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH". EMBO J. 16 (5): 1093–102. doi:10.1093/emboj/16.5.1093. PMC 1169708. PMID 9118947.
  6. ^ "Entrez Gene: GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa".
  7. ^ a b c d e Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. doi:10.1073/pnas.94.11.5605. PMC 20825. PMID 9159119.
  8. ^ Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W (Jul 2004). "A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A". Nat. Genet. 36 (7): 714–9. doi:10.1038/ng1387. PMID 15220921.

Further reading[edit]

External links[edit]