Guanoclor

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Guanoclor
Guanoclor.png
Clinical data
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
ECHA InfoCard100.023.334 Edit this at Wikidata
Chemical and physical data
FormulaC9H12Cl2N4O
Molar mass263.12 g·mol−1
3D model (JSmol)
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Guanoclor (INN), also known as guanochlor, is a sympatholytic drug. It is known to bind to non-adrenergic sites in pig kidney membranes.[1]

Synthesis[edit]

When β-(2,6-dichlorophenoxy)ethyl bromide (1) is reacted with hydrazine to give 2, and this is reacted with S-methylthiourea, guanochlor (3) results.[2][3]

Guanoclor synthesis

References[edit]

  1. ^ Vigne, Paul; Michael Lazdunski; Christian Frelin (31 January 1989). "Guanabenz, guanochlor, guanoxan and idazoxan bind with high affinity to non-adrenergic sites in pig kidney membranes". European Journal of Pharmacology. 160 (2): 295–298. doi:10.1016/0014-2999(89)90503-7. PMID 2527160.
  2. ^ Durant, G. J.; Smith, G. M.; Spickett, R. G. W.; Wright, S. H. B. (1966). "Biologically Active Guanidines and Related Compounds. II. Some Antiinflammatory Aminoguanidines1". Journal of Medicinal Chemistry. 9 (1): 22–7. doi:10.1021/jm00319a005. PMID 5958955.
  3. ^ Prepn of free base and sulfate: BE 629613  (1963 to Pfizer), C.A. 60, 14437d (1964).