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Protein HIVEP1 PDB 1bbo.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesHIVEP1, CIRIP, CRYBP1, GAAP, MBP-1, PRDII-BF1, Schnurri-1, ZAS1, ZNF40, ZNF40A, human immunodeficiency virus type I enhancer binding protein 1
External IDsOMIM: 194540 MGI: 96100 HomoloGene: 1596 GeneCards: HIVEP1
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for HIVEP1
Genomic location for HIVEP1
Band6p24.1Start12,008,762 bp[1]
End12,164,999 bp[1]
RNA expression pattern
PBB GE HIVEP1 204512 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 6: 12.01 – 12.16 MbChr 13: 42.05 – 42.19 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Zinc finger protein 40 is a protein that in humans is encoded by the HIVEP1 gene.[5][6]

Members of the ZAS family, such as ZAS1 (HIVEP1), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM][6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000095951 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021366 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Gaynor RB, Muchardt C, Diep A, Mohandas TK, Sparkes RS, Lusis AJ (Jul 1991). "Localization of the zinc finger DNA-binding protein HIV-EP1/MBP-1/PRDII-BF1 to human chromosome 6p22.3-p24". Genomics. 9 (4): 758–61. doi:10.1016/0888-7543(91)90371-K. PMID 2037300.
  6. ^ a b "Entrez Gene: HIVEP1 human immunodeficiency virus type I enhancer binding protein 1".

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.