HOXB5

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HOXB5
Protein HOXB5 PDB 1hom.png
Identifiers
AliasesHOXB5, HHO.C10, HOX2, HOX2A, HU-1, Hox2.1, homeobox B5
External IDsOMIM: 142960 MGI: 96186 HomoloGene: 37585 GeneCards: HOXB5
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for HOXB5
Genomic location for HOXB5
Band17q21.32Start48,591,257 bp[1]
End48,593,961 bp[1]
RNA expression pattern
PBB GE HOXB5 205601 s at fs.png

PBB GE HOXB5 205600 x at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002147

NM_008268

RefSeq (protein)

NP_002138

NP_032294

Location (UCSC)Chr 17: 48.59 – 48.59 MbChr 11: 96.3 – 96.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox protein Hox-B5 is a protein that in humans is encoded by the HOXB5 gene.[5][6][7]

Function[edit]

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.[7]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120075 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038700 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  6. ^ Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  7. ^ a b "Entrez Gene: HOXB5 homeobox B5".

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.