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Protein HOXB7 PDB 1ahd.png
AliasesHOXB7, HHO.C1, HOX2, HOX2C, Hox-2.3, homeobox B7
External IDsOMIM: 142962 MGI: 96188 HomoloGene: 55828 GeneCards: HOXB7
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for HOXB7
Genomic location for HOXB7
Band17q21.32Start48,607,227 bp[1]
End48,633,572 bp[1]
RNA expression pattern
PBB GE HOXB7 204779 s at fs.png

PBB GE HOXB8 204778 x at fs.png

PBB GE HOXB7 216973 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 17: 48.61 – 48.63 MbChr 11: 96.29 – 96.29 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Homeobox protein Hox-B7 is a protein that in humans is encoded by the HOXB7 gene.[5][6]


This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.[7]


HOXB7 has been shown to interact with PBX1[8] and CREB-binding protein.[9]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000260027 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038721 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  6. ^ Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  7. ^ "Entrez Gene: HOXB7 homeobox B7".
  8. ^ Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML (March 1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. 9 (6): 663–74. doi:10.1101/gad.9.6.663. PMID 7729685.
  9. ^ Chariot A, van Lint C, Chapelier M, Gielen J, Merville MP, Bours V (July 1999). "CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein". Oncogene. 18 (27): 4007–14. doi:10.1038/sj.onc.1202776. PMID 10435624.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.