This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in axial skeleton development and forelimb morphogenesis.
Limongi MZ, Pelliccia F, Gaddini L, Rocchi A (2000). "Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31→q32.1". Cytogenet. Cell Genet. 90 (1–2): 151–3. doi:10.1159/000015651. PMID11060466.
Patterson LT, Pembaur M, Potter SS (2001). "Hoxa11 and Hoxd11 regulate branching morphogenesis of the ureteric bud in the developing kidney". Development. 128 (11): 2153–61. PMID11493536.
Taketani T, Taki T, Shibuya N, et al. (2002). "The HOXD11 gene is fused to the NUP98 gene in acute myeloid leukemia with t(2;11)(q31;p15)". Cancer Res. 62 (1): 33–7. PMID11782354.
Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID11857506.
Boulet AM, Capecchi MR (2002). "Duplication of the Hoxd11 gene causes alterations in the axial and appendicular skeleton of the mouse". Dev. Biol. 249 (1): 96–107. doi:10.1006/dbio.2002.0755. PMID12217321.