Homeobox A10

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HOXA10
Identifiers
AliasesHOXA10, HOX1, HOX1.8, HOX1H, PL, Homeobox A10
External IDsOMIM: 142957 MGI: 96171 HomoloGene: 7365 GeneCards: HOXA10
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for HOXA10
Genomic location for HOXA10
Band7p15.2Start27,170,592 bp[1]
End27,180,261 bp[1]
RNA expression pattern
PBB GE HOXA10 213150 at fs.png

PBB GE HOXA10 213147 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018951
NM_153715

NM_001122950
NM_008263

RefSeq (protein)

NP_061824

NP_001116422
NP_032289

Location (UCSC)Chr 7: 27.17 – 27.18 MbChr 6: 52.23 – 52.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox protein Hox-A10 is a protein that in humans is encoded by the HOXA10 gene.[5][6][7]

Function[edit]

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described.[7] Downregualtion of HOXA10 is observed in the human and baboon decidua after implantation and this downregulation promotes trophoblast invasion by activating STAT3[8]

Interactions[edit]

Homeobox A10 has been shown to interact with PTPN6.[9]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000253293 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000938 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  6. ^ Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  7. ^ a b "Entrez Gene: HOXA10 homeobox A10".
  8. ^ Godbole, Geeta; Suman, Pankaj; Malik, Ankita; Galvankar, Mosami; Joshi, Niraj; Fazleabas, Asgi; Gupta, Satish; Modi, Deepak (2017). "Decrease in Expression of HOXA10 in the Decidua After Embryo Implantation Promotes Trophoblast Invasion". Endocrinology. 158 (8): 2618–2633. doi:10.1210/en.2017-00032. PMC 6283436. PMID 28520923.
  9. ^ Eklund EA, Goldenberg I, Lu Y, Andrejic J, Kakar R (Sep 2002). "SHP1 protein-tyrosine phosphatase regulates HoxA10 DNA binding and transcriptional repression activity in undifferentiated myeloid cells". The Journal of Biological Chemistry. 277 (39): 36878–88. doi:10.1074/jbc.M203917200. PMID 12145285.

Further reading[edit]

[1][2]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


  1. ^ Godbole, Geeta; Modi, Deepak (2010). "Regulation of decidualization, interleukin-11 and interleukin-15 by homeobox A 10 in endometrial stromal cells". American Journal of Reproductive Immunology. 85 (2): 130–139. doi:10.1016/j.jri.2010.03.003. PMID 20478621.
  2. ^ Godbole, Geeta; Puri, CP; Modi, Deepak (2007). "Regulation of homeobox A10 expression in the primate endometrium by progesterone and embryonic stimuli". Reproduction. 134 (3): 513–523. doi:10.1530/REP-07-0234. PMID 17709569.