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Available structures
PDBOrtholog search: PDBe RCSB
AliasesIL18RAP, ACPL, CD218b, CDw218b, IL-18R-beta, IL-18RAcP, IL-18Rbeta, IL-1R-7, IL-1R7, IL-1RAcPL, IL18RB, interleukin 18 receptor accessory protein
External IDsOMIM: 604509 MGI: 1338888 HomoloGene: 2859 GeneCards: IL18RAP
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for IL18RAP
Genomic location for IL18RAP
Band2q12.1Start102,418,689 bp[1]
End102,452,565 bp[1]
RNA expression pattern
PBB GE IL18RAP 207072 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 2: 102.42 – 102.45 MbChr 1: 40.52 – 40.55 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is a human gene.[5][6]


The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-κB and MAPK8 (JNK) in response to IL18.[5]

Disease association[edit]

Variants at IL18RAP have been linked to susceptibility to Coeliac disease.[7]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115607 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026068 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: IL18RAP interleukin 18 receptor accessory protein".
  6. ^ Born TL, Thomassen E, Bird TA, Sims JE (November 1998). "Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling". J. Biol. Chem. 273 (45): 29445–50. doi:10.1074/jbc.273.45.29445. PMID 9792649.
  7. ^ Hunt KA, Zhernakova A, Turner G, Heap GA, Franke L, Bruinenberg M, Romanos J, Dinesen LC, Ryan AW, Panesar D, Gwilliam R, Takeuchi F, McLaren WM, Holmes GK, Howdle PD, Walters JR, Sanders DS, Playford RJ, Trynka G, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, O'Morain C, Kennedy NP, Kelleher D, Pennington DJ, Strachan DP, McArdle WL, Mein CA, Wapenaar MC, Deloukas P, McGinnis R, McManus R, Wijmenga C, van Heel DA (April 2008). "Novel celiac disease genetic determinants related to the immune response". Nat. Genet. 40 (4): 395–402. doi:10.1038/ng.102. PMC 2673512. PMID 18311140.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.