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Available structures
PDBOrtholog search: PDBe RCSB
AliasesIL1F10, FIL1-theta, IL-1HY2, IL-38, IL1-theta, IL1HY2, FKSG75, interleukin 1 family member 10 (theta), interleukin 1 family member 10
External IDsOMIM: 615296 MGI: 2652548 HomoloGene: 17690 GeneCards: IL1F10
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for IL1F10
Genomic location for IL1F10
Band2q14.1Start113,067,970 bp[1]
End113,075,843 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 2: 113.07 – 113.08 MbChr 2: 24.29 – 24.29 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Interleukin-1 family member 10 is a protein that in humans is encoded by the IL1F10 gene.[5][6][7][8]

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136697 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046845 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bensen JT, Dawson PA, Mychaleckyj JC, Bowden DW (Dec 2001). "Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14". J Interferon Cytokine Res. 21 (11): 899–904. doi:10.1089/107999001753289505. PMID 11747621.
  6. ^ Taylor SL, Renshaw BR, Garka KE, Smith DE, Sims JE (May 2002). "Genomic organization of the interleukin-1 locus". Genomics. 79 (5): 726–33. doi:10.1006/geno.2002.6752. PMID 11991723.
  7. ^ Nicklin MJ, Barton JL, Nguyen M, FitzGerald MG, Duff GW, Kornman K (May 2002). "A sequence-based map of the nine genes of the human interleukin-1 cluster". Genomics. 79 (5): 718–25. doi:10.1006/geno.2002.6751. PMID 11991722.
  8. ^ a b "Entrez Gene: IL1F10 interleukin 1 family, member 10 (theta)".

Further reading[edit]