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AliasesIL36B, FIL1, FIL1-(ETA), FIL1H, FILI-(ETA), IL-1F8, IL-1H2, IL1-ETA, IL1F8, IL1H2, interleukin 36, beta, interleukin 36 beta
External IDsOMIM: 605508 MGI: 1916927 HomoloGene: 18278 GeneCards: IL36B
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for IL36B
Genomic location for IL36B
Band2q14.1Start113,022,089 bp[1]
End113,052,867 bp[1]
RNA expression pattern
PBB GE IL1F8 gnf1h00165 at fs.png

PBB GE IL1F8 gnf1h02208 at fs.png

PBB GE IL1F8 gnf1h02207 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 2: 113.02 – 113.05 MbChr 2: 24.15 – 24.16 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Interleukin-36 beta also known as interleukin-1 family member 8 (IL1F8) is a protein that in humans is encoded by the IL36B gene.[5][6][7][8]


The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136696 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026985 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE (Feb 2000). "Four new members expand the interleukin-1 superfamily". J Biol Chem. 275 (2): 1169–75. doi:10.1074/jbc.275.2.1169. PMID 10625660.
  6. ^ Mulero JJ, Pace AM, Nelken ST, Loeb DB, Correa TR, Drmanac R, Ford JE (Nov 1999). "IL1HY1: A novel interleukin-1 receptor antagonist gene". Biochem Biophys Res Commun. 263 (3): 702–6. doi:10.1006/bbrc.1999.1440. PMID 10512743.
  7. ^ Magne D, Palmer G, Barton JL, Mezin F, Talabot-Ayer D, Bas S, Duffy T, Noger M, Guerne PA, Nicklin MJ, Gabay C (Jun 2006). "The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes". Arthritis Research & Therapy. 8 (3): R80. doi:10.1186/ar1946. PMC 1526623. PMID 16646978.
  8. ^ a b "Entrez Gene: IL1F8 interleukin 1 family, member 8 (eta)".

Further reading[edit]