Inosine monophosphate synthase

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Protein ATIC PDB 1p4r.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesATIC, AICAR, AICARFT, HEL-S-70p, IMPCHASE, PURH, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
External IDsOMIM: 601731 MGI: 1351352 HomoloGene: 2983 GeneCards: ATIC
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for ATIC
Genomic location for ATIC
Band2q35Start215,311,956 bp[1]
End215,349,773 bp[1]
RNA expression pattern
PBB GE ATIC 208758 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 2: 215.31 – 215.35 MbChr 1: 71.56 – 71.58 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Bifunctional purine biosynthesis protein PURH is a protein that in humans is encoded by the ATIC gene.[5][6][7]

ATIC encodes an enzyme which generates inosine monophosphate from aminoimidazole carboxamide ribonucleotide.

It has two functions:

  • EC - 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase
  • EC - IMP cyclohydrolase


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138363 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026192 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Rayl EA, Moroson BA, Beardsley GP (Mar 1996). "The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping". J Biol Chem. 271 (4): 2225–33. doi:10.1074/jbc.271.4.2225. PMID 8567683.
  6. ^ Sugita T, Aya H, Ueno M, Ishizuka T, Kawashima K (Nov 1997). "Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase". J Biochem. 122 (2): 309–13. doi:10.1093/oxfordjournals.jbchem.a021754. PMID 9378707.
  7. ^ "Entrez Gene: ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase".

Further reading[edit]

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