Interleukin-9 receptor

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
AliasesIL9R, CD129, IL-9R, interleukin 9 receptor
External IDsOMIM: 300007 MGI: 96564 HomoloGene: 37591 GeneCards: IL9R
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for IL9R
Genomic location for IL9R
BandXq28 and Yq12Start155,997,581 bp[1]
End156,010,817 bp[1]
RNA expression pattern
PBB GE IL9R 208164 s at fs.png

PBB GE IL9R 217212 s at fs.png

PBB GE IL9R 214950 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr X: 156 – 156.01 MbChr 11: 32.19 – 32.2 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Interleukin 9 receptor (IL9R) also known as CD129 (Cluster of Differentiation 129) is a type I cytokine receptor. IL9R also denotes its human gene.[5]

The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses.  This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[5]


Interleukin-9 receptor has been shown to interact with YWHAZ.[6]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124334 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020279 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: IL9R interleukin 9 receptor".
  6. ^ Sliva, D; Gu M; Zhu Y X; Chen J; Tsai S; Du X; Yang Y C (February 2000). "14-3-3zeta interacts with the alpha-chain of human interleukin 9 receptor". Biochem. J. 345 Pt 3 (3): 741–7. doi:10.1042/0264-6021:3450741. ISSN 0264-6021. PMC 1220812. PMID 10642536.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.