Iroquois homeobox factor
Iroquois homeobox factors are a family of homeodomain transcription factors that play a role in many developmental processes. The loci were named for the flies carrying mutations in one of these genes, which are devoid of all bristles in the lateral part of the notum, leaving only a median stripe of bristles, similar to the Iroquois tribes which shaved all but a medial stripe of hairs on the head.
Human genes that encode Iroquois homeobox factors include:
- Gómez-Skarmeta JL, Modolell J (August 2002). "Iroquois genes: genomic organization and function in vertebrate neural development". Curr. Opin. Genet. Dev. 12 (4): 403–8. doi:10.1016/S0959-437X(02)00317-9. PMID 12100884.
- Kerner P, Ikmi A, Coen D, Vervoort M (2009). "Evolutionary history of the iroquois/Irx genes in metazoans". BMC Evol. Biol. 9: 74. doi:10.1186/1471-2148-9-74. PMC 2674049. PMID 19368711.
- Leyns L, Gómez-Skarmeta JL, Dambly-Chaudière C (September 1996). "iroquois: a prepattern gene that controls the formation of bristles on the thorax ofDrosophila". Mech. Dev. 59 (1): 63–72. PMID 8892233.