JUNB

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JUNB
Identifiers
AliasesJUNB, AP-1, JunB proto-oncogene, AP-1 transcription factor subunit
External IDsOMIM: 165161 MGI: 96647 HomoloGene: 7390 GeneCards: JUNB
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for JUNB
Genomic location for JUNB
Band19p13.13Start12,791,486 bp[1]
End12,793,315 bp[1]
RNA expression pattern
PBB GE JUNB 201473 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002229

NM_008416

RefSeq (protein)

NP_002220

NP_032442

Location (UCSC)Chr 19: 12.79 – 12.79 MbChr 8: 84.97 – 84.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor jun-B is a protein that in humans is encoded by the JUNB gene.[5][6] Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'.

Interactions[edit]

JUNB has been shown to interact with

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171223 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052837 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Schütte J, Viallet J, Nau M, Segal S, Fedorko J, Minna J (Feb 1990). "jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun". Cell. 59 (6): 987–997. doi:10.1016/0092-8674(89)90755-1. PMID 2513129.
  6. ^ "Entrez Gene: JUNB jun B proto-oncogene".
  7. ^ Hu YF, Li R (Jun 2002). "JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction". Genes Dev. 16 (12): 1509–17. doi:10.1101/gad.995502. PMC 186344. PMID 12080089.
  8. ^ Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF (Apr 1999). "Smads bind directly to the Jun family of AP-1 transcription factors". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 4844–9. doi:10.1073/pnas.96.9.4844. PMC 21779. PMID 10220381.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.