JWH-249 ( 1-pentyl-3-(2-bromophenylacetyl)indole) is a synthetic cannabinoid from the phenylacetylindole family, which acts as a cannabinoid agonist with about 2.4 times selectivity for CB with a 1 K of 8.4 ± 1.8 nM and 20 ± 2 nM at i CB. Similar to the related 2'- 2 methoxy compound JWH-250, the 2'- chloro compound JWH-203, and the 2'- methyl compound JWH-251, JWH-249 has a phenyl acetyl group in place of the naphthoyl ring used in most aminoalkylindole cannabinoid compounds. 
In the United States, CB
1 receptor agonists of the 3-phenylacetylindole class such as cannabipiperidiethanone are Schedule I Controlled Substances.
See also [ edit ]
References [ edit ]
Huffman JW, Szklennik PV, Almond A, Bushell K, Selley DE, He H, Cassidy MP, Wiley JL, Martin BR (2005). "1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles". Bioorganic & Medicinal Chemistry Letters. 15 (18): 4110–3. doi: 10.1016/j.bmcl.2005.06.008. PMID 16005223.
Manera C, Tuccinardi T, Martinelli A (2008). "Indoles and related compounds as cannabinoid ligands". Mini Reviews in Medicinal Chemistry. 8 (4): 370–87. doi: 10.2174/138955708783955935. PMID 18473928.
: 21 U.S.C. § 812 Schedules of controlled substances