KCNU1

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KCNU1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKCNU1, KCNMC1, KCa5, KCa5.1, Kcnma3, Slo3, potassium calcium-activated channel subfamily U member 1
External IDsOMIM: 615215 MGI: 1202300 HomoloGene: 7392 GeneCards: KCNU1
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for KCNU1
Genomic location for KCNU1
Band8p11.23Start36,784,324 bp[1]
End36,936,125 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001031836

NM_008432

RefSeq (protein)

NP_001027006

NP_032458

Location (UCSC)Chr 8: 36.78 – 36.94 MbChr 8: 25.85 – 25.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Potassium channel, subfamily U, member 1, also known as KCNU1, is a gene encoding the KCa5.1 protein.[5]

Although this channel is structurally related to the calcium-activated potassium channels, it cannot be classified as such since it is activated by high intracellular pH and relatively insensitive to changes in calcium concentrations.[6][7][8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000215262 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031576 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Schreiber M, Wei A, Yuan A, Gaut J, Saito M, Salkoff L (February 1998). "Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes". J. Biol. Chem. 273 (6): 3509–16. doi:10.1074/jbc.273.6.3509. PMID 9452476.
  6. ^ Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels". Pharmacol Rev. 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103.
  7. ^ Zhang X, Zeng X, Xia XM, Lingle CJ (September 2006). "pH-regulated Slo3 K+ channels: properties of unitary currents". J. Gen. Physiol. 128 (3): 301–15. doi:10.1085/jgp.200609551. PMC 2151565. PMID 16940554.
  8. ^ Zhang X, Zeng X, Lingle CJ (September 2006). "Slo3 K+ channels: voltage and pH dependence of macroscopic currents". J. Gen. Physiol. 128 (3): 317–36. doi:10.1085/jgp.200609552. PMC 2151566. PMID 16940555.

Celia M. Santi, Alice Butler, Julia Kuhn, Aguan Wei, Lawrence Salkoff. Bovine and mouse SLO3 K+ channels: Evolutionary divergence points to a RCK1 region of critical function. J Biol Chem.284: 21589-98 (2009).

Further reading[edit]

Celia M. Santi, Alice Butler, Julia Kuhn, Aguan Wei, Lawrence Salkoff. Bovine and mouse SLO3 K+ channels: Evolutionary divergence points to a RCK1 region of critical function. J Biol Chem.284: 21589-98 (2009).