LIM domain only 2 (rhombotin-like 1), also known as LMO2, RBTNL1, RBTN2, RHOM2, LIM Domain Only Protein 2, TTG2, and T-Cell Translocation Protein 2, is a protein which in humans is encoded by the LMO2gene.
LMO2 encodes a cysteine-rich, two LIM domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved.
The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number of T-cell acute lymphoblastic leukemia-specific translocations occur.
Royer-Pokora B, Loos U, Ludwig WD (Oct 1991). "TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11)". Oncogene. 6 (10): 1887–93. PMID1923511.
Boehm T, Spillantini MG, Sofroniew MV, Surani MA, Rabbitts TH (May 1991). "Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression". Oncogene. 6 (5): 695–703. PMID2052354.
Dong WF, Xu Y, Hu QL, Munroe D, Minowada J, Housman DE, Minden MD (Nov 1995). "Molecular characterization of a chromosome translocation breakpoint t(11;14)(p13;q11) from the cell line KOPT-K1". Leukemia. 9 (11): 1812–7. PMID7475267.
Wilkinson DA, Neale GA, Mao S, Naeve CW, Goorha RM (Jan 1997). "Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia". Leukemia. 11 (1): 86–96. doi:10.1038/sj.leu.2400516. PMID9001422.
Mao S, Neale GA, Goorha RM (Apr 1997). "T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2". Oncogene. 14 (13): 1531–9. doi:10.1038/sj.onc.1200988. PMID9129143.
Osada H, Grutz GG, Axelson H, Forster A, Rabbitts TH (Apr 1997). "LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1". Leukemia. 11 Suppl 3: 307–12. PMID9209374.
Davenport J, Neale GA, Goorha R (Nov 2000). "Identification of genes potentially involved in LMO2-induced leukemogenesis". Leukemia. 14 (11): 1986–96. doi:10.1038/sj.leu.2401913. PMID11069036.
Sum EY, Peng B, Yu X, Chen J, Byrne J, Lindeman GJ, Visvader JE (Mar 2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". The Journal of Biological Chemistry. 277 (10): 7849–56. doi:10.1074/jbc.M110603200. PMID11751867.