Laminin, alpha 5

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LAMA5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLAMA5, Laminin, alpha 5, laminin subunit alpha 5
External IDsOMIM: 601033 MGI: 105382 HomoloGene: 4060 GeneCards: LAMA5
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for LAMA5
Genomic location for LAMA5
Band20q13.33Start62,307,955 bp[1]
End62,367,312 bp[1]
RNA expression pattern
PBB GE LAMA5 210150 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005560

NM_001081171

RefSeq (protein)

NP_005551

NP_001074640

Location (UCSC)Chr 20: 62.31 – 62.37 MbChr 2: 180.18 – 180.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Laminin subunit alpha-5 is a protein that in humans is encoded by the LAMA5 gene.[5][6]

Function[edit]

Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined.[6]

Interactions[edit]

Laminin, alpha 5 has been shown to interact with BCAM.[7][8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130702 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015647 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Durkin ME, Loechel F, Mattei MG, Gilpin BJ, Albrechtsen R, Wewer UM (Jul 1997). "Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation". FEBS Letters. 411 (2–3): 296–300. doi:10.1016/S0014-5793(97)00686-8. PMID 9271224.
  6. ^ a b "Entrez Gene: LAMA5 laminin, alpha 5".
  7. ^ Parsons SF, Lee G, Spring FA, Willig TN, Peters LL, Gimm JA, Tanner MJ, Mohandas N, Anstee DJ, Chasis JA (Jan 2001). "Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity". Blood. 97 (1): 312–20. doi:10.1182/blood.V97.1.312. PMID 11133776.
  8. ^ Kikkawa Y, Moulson CL, Virtanen I, Miner JH (Nov 2002). "Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo". The Journal of Biological Chemistry. 277 (47): 44864–9. doi:10.1074/jbc.M208731200. PMID 12244066.

Further reading[edit]