MTF1

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MTF1
Identifiers
AliasesMTF1, MTF-1, ZRF, metal-regulatory transcription factor 1, metal regulatory transcription factor 1
External IDsMGI: 101786 HomoloGene: 4347 GeneCards: MTF1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for MTF1
Genomic location for MTF1
Band1p34.3Start37,809,574 bp[1]
End37,859,592 bp[1]
RNA expression pattern
PBB GE MTF1 205322 s at fs.png

PBB GE MTF1 205323 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005955

NM_008636

RefSeq (protein)

NP_005946

NP_032662

Location (UCSC)Chr 1: 37.81 – 37.86 MbChr 4: 124.8 – 124.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Metal regulatory transcription factor 1 is a protein that in humans is encoded by the MTF1 gene.[5][6]

Function[edit]

This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000188786 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028890 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Brugnera E, Georgiev O, Radtke F, Heuchel R, Baker E, Sutherland GR, Schaffner W (Aug 1994). "Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1". Nucleic Acids Research. 22 (15): 3167–73. doi:10.1093/nar/22.15.3167. PMC 310292. PMID 8065932.
  6. ^ a b "Entrez Gene: MTF1 metal-regulatory transcription factor 1".

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.