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AliasesMXD3, BHLHC13, MAD3, MYX, MAX dimerization protein 3
External IDsOMIM: 609450 MGI: 104987 HomoloGene: 32333 GeneCards: MXD3
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for MXD3
Genomic location for MXD3
Band5q35.3Start177,301,461 bp[1]
End177,312,757 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 5: 177.3 – 177.31 MbChr 13: 55.33 – 55.33 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

MAX dimerization protein 3 is a protein that in humans is encoded by the MXD3 gene located on Chromosome 5.[5][6]

MXD3 is a basic helix-loop-helix protein belonging to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex.[6] MXD3 is a transcriptional repressor that is specifically expressed during S phase of the cell cycle.[7] The protein is implicated in both normal neural development and in the development of brain cancer. In medulloblastoma cells, MXD3 binds E-box sequences, leading to increased cell proliferation at moderate MXD3 levels but increased cell death and apoptosis at higher expression levels.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000213347 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021485 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hurlin PJ, Quéva C, Koskinen PJ, Steingrímsson E, Ayer DE, Copeland NG, Jenkins NA, Eisenman RN (November 1995). "Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation". EMBO J. 14 (22): 5646–59. PMC 394680. PMID 8521822.
  6. ^ a b "Entrez Gene: MXD3 MAX dimerization protein 3".
  7. ^ Fox EJ, Wright SC (February 2003). "The transcriptional repressor gene Mad3 is a novel target for regulation by E2F1". Biochem J. 370 (1): 307–13. doi:10.1042/bj20021583. PMC 1223166. PMID 12444919.
  8. ^ Barisone GA, Ngo T, Tran M, Cortes D, Shahi MH, Nguyen TV, Perez-Lanza D, Matayasuwan W, Díaz E (July 2012). "Role of MXD3 in proliferation of DAOY human medulloblastoma cells". PLOS ONE. 7 (7): e38508. doi:10.1371/journal.pone.0038508. PMC 3393725. PMID 22808009.