MYCL

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MYCL
Identifiers
AliasesMYCL, LMYC, MYCL1, bHLHe38, L-Myc, v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog, MYCL proto-oncogene, bHLH transcription factor
External IDsMGI: 96799 HomoloGene: 3921 GeneCards: MYCL
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for MYCL
Genomic location for MYCL
Band1p34.2Start39,895,426 bp[1]
End39,902,256 bp[1]
RNA expression pattern
PBB GE MYCL1 214058 at fs.png

PBB GE MYCL1 215491 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005376
NM_001033081
NM_001033082

NM_008506
NM_001303121

RefSeq (protein)

NP_001028253
NP_001028254
NP_005367

NP_001290050
NP_032532

Location (UCSC)Chr 1: 39.9 – 39.9 MbChr 4: 123 – 123 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene.[5][6]

MYCL1 is a bHLH (basic helix-loop-helix) transcription factor implicated in lung cancer.[7]

Interactions[edit]

MYCL1 has been shown to interact with MAX.[8][9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116990 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028654 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Speleman F, Van Camp G, Van Roy N (Jan 1997). "Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in situ hybridization". Cytogenet Cell Genet. 72 (2–3): 189–190. doi:10.1159/000134185. PMID 8978772.
  6. ^ "Entrez Gene: MYCL1 v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)".
  7. ^ Ikegaki N, Minna J, Kennett RH (1989). "The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences". EMBO J. 8 (6): 1793–9. PMC 401025. PMID 2548855.
  8. ^ Blackwood EM, Eisenman RN (Mar 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc". Science. 251 (4998): 1211–1217. doi:10.1126/science.2006410. PMID 2006410.
  9. ^ FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE (Apr 1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene. 18 (15): 2489–2498. doi:10.1038/sj.onc.1202611. PMID 10229200.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.