Megakaryocyte-associated tyrosine kinase

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Protein MATK PDB 1jwo.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesMATK, CHK, CTK, HHYLTK, HYL, HYLTK, Lsk, Megakaryocyte-associated tyrosine kinase
External IDsOMIM: 600038 MGI: 99259 HomoloGene: 48104 GeneCards: MATK
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for MATK
Genomic location for MATK
Band19p13.3Start3,777,970 bp[1]
End3,802,129 bp[1]
RNA expression pattern
PBB GE MATK 206267 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 19: 3.78 – 3.8 MbChr 10: 81.25 – 81.26 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Megakaryocyte-associated tyrosine-protein kinase is an enzyme that in humans is encoded by the MATK gene.[5][6][7]

The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene.[7]


Megakaryocyte-associated tyrosine kinase has been shown to interact with CD117[8][9] and TrkA.[10]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000007264 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004933 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bennett BD, Cowley S, Jiang S, London R, Deng B, Grabarek J, Groopman JE, Goeddel DV, Avraham H (February 1994). "Identification and characterization of a novel tyrosine kinase from megakaryocytes". J Biol Chem. 269 (2): 1068–74. PMID 8288563.
  6. ^ Avraham S, Jiang S, Ota S, Fu Y, Deng B, Dowler LL, White RA, Avraham H (February 1995). "Structural and functional studies of the intracellular tyrosine kinase MATK gene and its translated product". J Biol Chem. 270 (4): 1833–42. doi:10.1074/jbc.270.4.1833. PMID 7530249.
  7. ^ a b "Entrez Gene: MATK megakaryocyte-associated tyrosine kinase".
  8. ^ Jhun, B H; Rivnay B; Price D; Avraham H (April 1995). "The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit". J. Biol. Chem. UNITED STATES. 270 (16): 9661–6. doi:10.1074/jbc.270.16.9661. ISSN 0021-9258. PMID 7536744.
  9. ^ Price, D J; Rivnay B; Fu Y; Jiang S; Avraham S; Avraham H (February 1997). "Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes". J. Biol. Chem. UNITED STATES. 272 (9): 5915–20. doi:10.1074/jbc.272.9.5915. ISSN 0021-9258. PMID 9038210.
  10. ^ Yamashita, H; Avraham S; Jiang S; Dikic I; Avraham H (May 1999). "The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells". J. Biol. Chem. UNITED STATES. 274 (21): 15059–65. doi:10.1074/jbc.274.21.15059. ISSN 0021-9258. PMID 10329710.

Further reading[edit]