N-acetylornithine carbamoyltransferase

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N-acetylornithine carbamoyltransferase
EC number2.1.3.9
CAS number890853-54-0
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a N-acetylornithine carbamoyltransferase (EC is an enzyme that catalyzes the chemical reaction

carbamoyl phosphate + N2-acetyl-L-ornithine phosphate + N-acetyl-L-citrulline

Thus, the two substrates of this enzyme are carbamoyl phosphate and N2-acetyl-L-ornithine, whereas its two products are phosphate and N-acetyl-L-citrulline.

This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the carboxy- and carbamoyltransferases. The systematic name of this enzyme class is carbamoyl-phosphate:N2-acetyl-L-ornithine carbamoyltransferase. Other names in common use include acetylornithine transcarbamylase, N-acetylornithine transcarbamylase, AOTC, and carbamoyl-phosphate:2-N-acetyl-L-ornithine carbamoyltransferase.

Structural studies[edit]

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 2G65, 2G68, 2G6A, and 2G6C.


  • Shi D, Morizono H, Yu X, Roth L, Caldovic L, Allewell NM, Malamy MH, Tuchman M (April 2005). "Crystal structure of N-acetylornithine transcarbamylase from Xanthomonas campestris: a novel enzyme in a new arginine biosynthetic pathway found in several eubacteria". The Journal of Biological Chemistry. 280 (15): 14366–9. doi:10.1074/jbc.C500005200. PMID 15731101.