NFATC3

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NFATC3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNFATC3, NFAT4, NFATX, nuclear factor of activated T-cells 3, nuclear factor of activated T cells 3, NF-AT4c
External IDsOMIM: 602698 MGI: 103296 HomoloGene: 27827 GeneCards: NFATC3
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for NFATC3
Genomic location for NFATC3
Band16q22.1Start68,084,751 bp[1]
End68,229,259 bp[1]
RNA expression pattern
PBB GE NFATC3 210556 at fs.png

PBB GE NFATC3 210555 s at fs.png

PBB GE NFATC3 207416 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_173165
NM_004555
NM_173163
NM_173164

NM_010901
NM_001368796
NM_001368797

RefSeq (protein)

NP_004546
NP_775186
NP_775188
NP_004546.1
NP_775188.1

n/a

Location (UCSC)Chr 16: 68.08 – 68.23 MbChr 8: 106.06 – 106.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nuclear factor of activated T-cells, cytoplasmic 3 is a protein that in humans is encoded by the NFATC3 gene.[5][6]

Function[edit]

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Four transcript variants encoding distinct isoforms have been identified for this gene.[6]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000072736 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031902 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hoey T, Sun YL, Williamson K, Xu X (May 1995). "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins". Immunity. 2 (5): 461–72. doi:10.1016/1074-7613(95)90027-6. PMID 7749981.
  6. ^ a b "Entrez Gene: NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3".

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.