2010 marked the inaugural event of the Nashville 200. In October 2009, the parent company of the Superspeedway, Dover Motorsports, Inc. announced that it would be closing Memphis Motorsports Park, which was previously scheduled to host a Truck Series race on June 26. It was announced shortly afterward that the Memphis race would be replaced with a second race at Nashville. The race, which was scheduled for April 2, would mark the opening race of a doubleheader with the Nationwide Series, which would race the following day at the track.
With the first race, Nashville Superspeedway would become the only race track on the schedule to host two Camping World Truck Series races and not host a NASCAR Sprint Cup Series event. The race was only run twice, as the track was shut down following the 2011 season.