Neuropeptide B/W receptor

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neuropeptides B/W receptor 1
Identifiers
SymbolNPBWR1
Alt. symbolsGPR7
NCBI gene2831
HGNC4522
OMIM600730
RefSeqNM_005285
UniProtP48145
Other data
LocusChr. 8 p22-q21.13
neuropeptides B/W receptor 2
Identifiers
SymbolNPBWR2
Alt. symbolsGPR8
NCBI gene2832
HGNC4530
OMIM600731
RefSeqNM_005286
UniProtP48146
Other data
LocusChr. 20 q13.3

The neuropeptide B/W receptors are members of the G-protein coupled receptor superfamily of integral membrane proteins which bind the neuropeptides B and W.[1] These receptors are predominantly expressed in the CNS and have a number of functions including regulation of the secretion of cortisol.[2][3]

References[edit]

  1. ^ Tanaka H, Yoshida T, Miyamoto N, Motoike T, Kurosu H, Shibata K, Yamanaka A, Williams SC, Richardson JA, Tsujino N, Garry MG, Lerner MR, King DS, O'Dowd BF, Sakurai T, Yanagisawa M (2003). "Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6251–6. doi:10.1073/pnas.0837789100. PMC 156358. PMID 12719537.
  2. ^ Mazzocchi G, Rebuffat P, Ziolkowska A, Rossi GP, Malendowicz LK, Nussdorfer GG (2005). "G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades". J. Clin. Endocrinol. Metab. 90 (6): 3466–71. doi:10.1210/jc.2004-2132. PMID 15797961.
  3. ^ Singh G, Davenport AP (2006). "Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system". Br. J. Pharmacol. 148 (8): 1033–41. doi:10.1038/sj.bjp.0706825. PMC 1752024. PMID 16847439.

External links[edit]