PF-219,061

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PF-219,061
PF-219,061 Structural Formulae.png
Clinical data
Routes of
administration
Nasal
Legal status
Legal status
  • Investigational (discontinued)
Identifiers
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC13H19NO2
Molar mass221.295 g/mol g·mol−1
3D model (JSmol)
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PF-219,061 is a drug that was under development by Pfizer which acts as a potent and highly selective agonist for the dopamine D3 receptor.[1][2] It was under development as a potential medication for the treatment of female sexual dysfunction.[3][4] It did not advance into clinical trials.[5]

See also[edit]

References[edit]

  1. ^ Blagg, J; Allerton, C. M.; Batchelor, D. V.; Baxter, A. D.; Burring, D. J.; Carr, C. L.; Cook, A. S.; Nichols, C. L.; Phipps, J; Sanderson, V. G.; Verrier, H; Wong, S (2007). "Design and synthesis of a functionally selective D3 agonist and its in vivo delivery via the intranasal route". Bioorganic & Medicinal Chemistry Letters. 17 (24): 6691–6. doi:10.1016/j.bmcl.2007.10.059. PMID 17976986.
  2. ^ Brioni, Jorge D.; Moreland, Robert B. (2006). "Dopamine D4 receptors and the regulation of penile erection". Drug Discovery Today: Therapeutic Strategies. 3 (4): 599. doi:10.1016/j.ddstr.2006.10.006.
  3. ^ Van Der Graaf et al. Selective Dopamine D3 Receptor Agonists for the Treatment of Sexual Dysfunction, WIPO Patent WO/2003/051370, granted to Pfizer
  4. ^ Attkins, N. J.; Heatherington, A. C.; Phipps, J; Verrier, H; Huyghe, I (2009). "Predictability of intranasal pharmacokinetics in man using pre-clinical pharmacokinetic data with a dopamine 3 receptor agonist, PF-219061". Xenobiotica. 39 (7): 523–33. doi:10.1080/00498250902893775. PMID 19480558.
  5. ^ Antoni Cortés, Estefanía Moreno, Mar Rodríguez-Ruiz, Enric I. Canela, and Vicent Casadó (2016). "Targeting the dopamine D3 receptor: an overview of drug design strategies". Expert Opinion on Drug Discovery. 11 (7): 641–64. doi:10.1080/17460441.2016.1185413. PMID 27135354.CS1 maint: multiple names: authors list (link)