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AliasesPOU4F2, BRN3.2, BRN3B, Brn-3b, POU class 4 homeobox 2
External IDsMGI: 102524 HomoloGene: 20959 GeneCards: POU4F2
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for POU4F2
Genomic location for POU4F2
Band4q31.22Start146,638,893 bp[1]
End146,642,474 bp[1]
RNA expression pattern
PBB GE POU4F2 207725 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 4: 146.64 – 146.64 MbChr 8: 78.43 – 78.44 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

POU domain, class 4, transcription factor 2 is a protein that in humans is encoded by the POU4F2 gene.[5][6]


POU4F2 is a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. A class IV POU-domain protein, POU4F2 is found in human retina exclusively within a subpopulation of ganglion cells where it may play a role in determining or maintaining the identities of a small subset of visual system neurons.[supplied by OMIM][6]


POU4F2 has been shown to interact with Estrogen receptor alpha.[7]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000151615 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031688 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Ring CJ, Latchman DS (Jun 1993). "The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain". Nucleic Acids Research. 21 (12): 2946. doi:10.1093/nar/21.12.2946. PMC 309696. PMID 8332509.
  6. ^ a b "Entrez Gene: POU4F2 POU domain, class 4, transcription factor 2".
  7. ^ Budhram-Mahadeo V, Parker M, Latchman DS (Feb 1998). "POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element". Molecular and Cellular Biology. 18 (2): 1029–41. doi:10.1128/mcb.18.2.1029. PMC 108815. PMID 9448000.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.