|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||263.38 g/mol g·mol−1|
Pridefine (AHR-1,118) is a drug which was investigated as an antidepressant in the late 1970s and early 1980s, but was never marketed. It acts as a balanced reuptake inhibitor of serotonin, dopamine, and norepinephrine, and also has some weak releasing activity.
In clinical trials pridefine was found to be as efficacious as the tricyclic antidepressants amitriptyline and imipramine in the treatment of major depressive disorder but was much more tolerable in comparison and also had an earlier onset of action. It has been shown to be effective in the treatment of alcoholism as well.
- Vosmer G, DeMet EM, Halaris AE (1980). "Action of the antidepressant pridefine (AHR-1118) on biogenic amines in the rat brain". Biochemical Pharmacology. 29 (19): 2557–62. doi:10.1016/0006-2952(80)90066-0. PMID 7426062.
- Halaris AE, Demet EM (1980). "Open trial evaluation of a pyrrolidine derivative (AHR-1118) on norepinephrine metabolism". Progress in Neuro-Psychopharmacology. 4 (1): 43–9. doi:10.1016/0364-7722(80)90060-0. PMID 7406986.
- DeMet EM, Vosmer G, Halaris AE (1981). "Noncompetitive amine uptake inhibition by the new antidepressant pridefine". Journal of Neurochemistry. 36 (3): 917–23. doi:10.1111/j.1471-4159.1981.tb01682.x. PMID 7205281.