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Pyrithyldione ball-and-stick.png
Clinical data
Trade namesBenedorm, Didropyridine, Dihydroprylone, Persedon, Presidon, Pyridion, Pyridione, Pyrithyldion, Pyrithyldione, Tetridin, Tetridine
ATC code
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.000.910 Edit this at Wikidata
Chemical and physical data
Molar mass167.205 g/mol g·mol−1
3D model (JSmol)
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Pyrithyldione (Presidon, Persedon) is a psychoactive drug invented in 1949.[1] An improved method of manufacture was patented by Roche in 1959.[2] It was used as a hypnotic or sedative and presumed to be less toxic than barbiturates.[3] Today, this substance is no longer used. Agranulocytosis was sometimes reported as adverse effect.[4][5]

See also[edit]


  1. ^ Becker, E. L.; Fabing, H. D.; Hawkins, J. R. (1949). "Presidon; A New Sedative-Hypnotic". Christ Hospital Medical Bulletin. 2 (4): 80–84. PMID 18144514.
  2. ^ US patent 3019230, Hinderling, R.; Lutz, A. H. & Schnider, O., "Method for the preparation of 2,4-dioxo-tetrahydropyridines", issued 1962-01-30, assigned to Hoffmann-La Roche 
  3. ^ Pribilla, O. (1956). "Zur Toxikologie des Persedons". Archiv für Toxikologie. 16 (1): 34–49. doi:10.1007/BF00577351.
  4. ^ Ibáñez, L.; Ballarín, E.; Pérez, E.; Vidal, X.; Capellà, D.; Laporte, J. R. (2000). "Agranulocytosis Induced by Pyrithyldione, a Sedative Hypnotic Drug". European Journal of Clinical Pharmacology. 55 (10): 761–764. doi:10.1007/s002280050011. PMID 10663456.
  5. ^ Covner, A. H.; Halpern, S. L. (1950). "Fatal Agranulocytosis Following Therapy with Presidon (3,3-Diethyl-2,4-Dioxotetrahydropyridine), a New Sedative Hypnotic Agent". New England Journal of Medicine. 242 (2): 49–52. doi:10.1056/NEJM195001122420203. PMID 15399031.