RAD140

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RAD140
RAD140 structure.png
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC20H16ClN5O2
Molar mass393.83 g·mol−1
3D model (JSmol)

RAD140 is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer, currently under development by Radius Health, Inc. (RDUS).[1][2][3][4]

Health Effects[edit]

According to a study conducted by researchers at the University of Southern California, Los Angeles, RAD 140 appears to be safer than testosterone replacement therapy.[5]

Another study conducted in February 2011 found that RAD 140 (Testolone) drastically increases lean muscle mass, by targeting androgen receptors in skeletal tissue.[6]

While more research needs to be done, some recreational users report that RAD 140 can lead to rapid muscle gains, with minimal side effects.[7]

See also[edit]

References[edit]

  1. ^ Jayaraman, Anusha; Christensen, Amy; Moser, V. Alexandra; Vest, Rebekah S.; Miller, Chris P.; Hattersley, Gary; Pike, Christian J. (April 2014). "Selective Androgen Receptor Modulator RAD140 Is Neuroprotective in Cultured Neurons and Kainate-Lesioned Male Rats". Endocrinology. 155 (4): 1398–1406. doi:10.1210/en.2013-1725. ISSN 0013-7227. PMC 3959610. PMID 24428527.
  2. ^ Hamson, D. K.; Wainwright, S. R.; Taylor, J. R.; Jones, B. A.; Watson, N. V.; Galea, L. a. M. (September 2013). "Androgens Increase Survival of Adult-Born Neurons in the Dentate Gyrus by an Androgen Receptor-Dependent Mechanism in Male Rats". Endocrinology. 154 (9): 3294–3304. doi:10.1210/en.2013-1129. ISSN 0013-7227. PMID 23782943.
  3. ^ Miller, Chris P.; Shomali, Maysoun; Lyttle, C. Richard; O’Dea, Louis St. L.; Herendeen, Hillary; Gallacher, Kyla; Paquin, Dottie; Compton, Dennis R.; Sahoo, Bishwabhusan; Kerrigan, Sean A.; Burge, Matthew S.; Nickels, Michael; Green, Jennifer L.; Katzenellenbogen, John A.; Tchesnokov, Alexei; Hattersley, Gary (February 2011). "Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140". ACS Medicinal Chemistry Letters. 2 (2): 124–129. doi:10.1021/ml1002508. PMC 4018048. PMID 24900290.
  4. ^ Chris Miller; Maysoun Shomali; C Richard Lyttle; Gary Hattersley (24 June 2012). A Selective Androgen Receptor Modulator (RAD140) Induces Inflammation in Rat Right Heart Ventricle: Evidence for an Androgen-Specific, Species-Specific Mechanism. Roles of Androgen & Glucocorticoid Receptors in Physiology & Disease (Translational). Meeting Abstracts. The Endocrine Society. pp. SUN–525-SUN-525. doi:10.1210/endo-meetings.2012.nrsh.9.sun-525.
  5. ^ Jayaraman, Anusha; Christensen, Amy; Moser, V. Alexandra; Vest, Rebekah S.; Miller, Chris P.; Hattersley, Gary; Pike, Christian J. (April 2014). "Selective Androgen Receptor Modulator RAD140 Is Neuroprotective in Cultured Neurons and Kainate-Lesioned Male Rats". Endocrinology. 155 (4): 1398–1406. doi:10.1210/en.2013-1725. ISSN 0013-7227. PMC 3959610. PMID 24428527.
  6. ^ Miller, Chris P.; Shomali, Maysoun; Lyttle, C. Richard; O’Dea, Louis St. L.; Herendeen, Hillary; Gallacher, Kyla; Paquin, Dottie; Compton, Dennis R.; Sahoo, Bishwabhusan (2010-12-02). "Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140". ACS Medicinal Chemistry Letters. 2 (2): 124–129. doi:10.1021/ml1002508. ISSN 1948-5875. PMC 4018048. PMID 24900290.
  7. ^ "Full RAD 140 (Testolone) Guide: Dosage, Results, & More! (2019)". Masculine Development. 2019-05-17. Retrieved 2019-09-21.