Ro48-8684 is a water-soluble benzodiazepine derivative developed by Hoffman-LaRoche in the 1990s, which was designed along with Ro48-6791 as an improved replacement for midazolam, but ultimately proved to have little advantages over the parent drug and has not been introduced into clinical practice.
^van Gerven JM, Roncari G, Schoemaker RC, Massarella J, Keesmaat P, Kooyman H, Heizmann P, Zell M, Cohen AF, Dingemanse J. Integrated pharmacokinetics and pharmacodynamics of Ro 48-8684, a new benzodiazepine, in comparison with midazolam during first administration to healthy male subjects. British Journal of Clinical Pharmacology. 1997 Nov;44(5):487-93. PMID9384466
^Albrecht S, Hering W, Ihmsen H, Schwilden H, Schüttler J. Pharmacokinetic-pharmacodynamic modeling in phase II of drug development. A comparative study with young and old volunteers with benzdiazepine as an example. (German) Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie. 1999 Oct;34(10):634-7. PMID10548960