S-Adenosyl-L-homocysteine

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S-Adenosyl-l-homocysteine
S-Adenosyl-L-homocystein.svg
Names
IUPAC name
S-(5'-Deoxyadenos-5'-yl)-l-homocysteine
Other names
AdoHcy, 2-S-adenosyl-l-homocysteine,
5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine S-adenosylhomocysteine, SAH
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.012.328
KEGG
MeSH S-Adenosylhomocysteine
Properties
C14H20N6O5S
Molar mass 384.412
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

S-Adenosyl-l-homocysteine (SAH) is the biosynthetic precursor to homocysteine.[1] SAH is formed by the demethylation of S-adenosyl-l-methionine.[2][3] Adenosylhomocysteinase converts SAH into homocysteine and adenosine.

References[edit]

  1. ^ Finkelstein, J. D. (2000). "Pathways and regulation of homocysteine metabolism in mammals". Semin. Thromb. Hemost. 26: 219–225. doi:10.1055/s-2000-8466.
  2. ^ Ribbe, M. W.; Hu, Y.; Hodgson, K. O.; Hedman, B. (2014). "Biosynthesis of Nitrogenase Metalloclusters". Chem. Rev. 114: 4063–4080. doi:10.1021/cr400463x. PMC 3999185.
  3. ^ James, S. Jill; Melnyk, Stepan; Pogribna, Marta; Pogribny, Igor P; Caudill, Marie A (2002). "Elevation in S-Adenosylhomocysteine and DNA Hypomethylation: Potential Epigenetic Mechanism for Homocysteine-Related Pathology". The Journal of Nutrition. 132 (8): 2361S–2366S. doi:10.1093/jn/132.8.2361S. PMID 12163693.

External links[edit]