SEMA7A

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SEMA7A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSEMA7A, CD108, CDw108, H-SEMA-K1, H-Sema-L, JMH, SEMAK1, SEMAL, semaphorin 7A (John Milton Hagen blood group)
External IDsOMIM: 607961 MGI: 1306826 HomoloGene: 2678 GeneCards: SEMA7A
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for SEMA7A
Genomic location for SEMA7A
Band15q24.1Start74,409,289 bp[1]
End74,433,958 bp[1]
RNA expression pattern
PBB GE SEMA7A 210083 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003612
NM_001146029
NM_001146030

NM_011352

RefSeq (protein)

NP_001139501
NP_001139502
NP_003603

NP_035482

Location (UCSC)Chr 15: 74.41 – 74.43 MbChr 9: 57.94 – 57.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) (SEMA7A) also known as CD108 (Cluster of Differentiation 108), is a human gene.[5]

SEMA7A is a membrane-bound semaphorin that associates with cell surfaces via a glycosylphosphatidylinositol (GPI) linkage. SEMA7A is also known as the John-Milton-Hagen (JMH) blood group antigen, an 80-kD glycoprotein expressed on activated lymphocytes and erythrocytes.[supplied by OMIM][5]

Genetics[edit]

This protein is known to have eight variants in the extracellular region: seven lie within the Sema domain and one within the PSI domain.

Molecular biology[edit]

This protein forms dimers.

Notes[edit]

This protein acts as a receptor for the malaria parasite Plasmodium falciparum.

See also[edit]

References[edit]

  1. ^ a b c ENSG00000288455 GRCh38: Ensembl release 89: ENSG00000138623, ENSG00000288455 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038264 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)".

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.