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CAS number74434-59-6

Sauvagine is a protein that functions as a neuropeptide. It is 40 amino acids in length,[1] and has sequence XGPPISIDLSLELLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2, with a pyrrolidone carboxylic acid modification at the N-terminal and amidation of the C-terminal isoleucine residue. It was originally isolated from the skin of the frog Phyllomedusa sauvagei, but has been hypothesised to be produced endogenously by mammals, as it produces similar physiological effects to endogenous neuropeptides such as corticotropin-releasing hormone.[2][3]

Sauvagine belongs to the corticotropin-releasing factor (CRF) family that also includes CRF, urotensin I, urocortin, urocortin II and urocortin III.[4][5]


Sauvagine has been shown to interact with corticotropin releasing hormone receptors 1 and 2.


  1. ^ Montecucchi PC, Henschen A (August 1981). "Amino acid composition and sequence analysis of sauvagine, a new active peptide from the skin of Phyllomedusa sauvagei". International Journal of Peptide and Protein Research. 18 (2): 113–20. PMID 7309372.
  2. ^ Falaschi P, D'Urso R, Negri L, Rocco A, Montecucchi PC, Henschen A, Melchiorri P, Erspamer V (August 1982). "Potent in vivo and in vitro prolactin inhibiting activity of sauvagine, a frog skin peptide". Endocrinology. 111 (2): 693–5. doi:10.1210/endo-111-2-693. PMID 7094889.
  3. ^ Brown MR, Fisher LA, Spiess J, Rivier J, Rivier C, Vale W (July 1982). "Comparison of the biologic actions of corticotropin-releasing factor and sauvagine". Regulatory Peptides. 4 (2): 107–14. doi:10.1016/0167-0115(82)90101-X. PMID 6289384.
  4. ^ Fekete EM, Zorrilla EP (April 2007). "Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: ancient CRF paralogs". Frontiers in Neuroendocrinology. 28 (1): 1–27. doi:10.1016/j.yfrne.2006.09.002. PMC 2730896. PMID 17083971.
  5. ^ Lovejoy DA, de Lannoy L (December 2013). "Evolution and phylogeny of the corticotropin-releasing factor (CRF) family of peptides: expansion and specialization in the vertebrates". Journal of Chemical Neuroanatomy. 54: 50–6. doi:10.1016/j.jchemneu.2013.09.006. PMID 24076419.