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SoRI-9409 structure.png
PubChem CID
Chemical and physical data
Molar mass486.988 g/mol g·mol−1
3D model (JSmol)

SoRI-9409 is a mixed mu opioid receptor partial agonist and delta opioid receptor antagonist, used in biomedical research. It produces moderate analgesic effects without development of tolerance and with reduced withdrawal symptoms compared to standard opioid analgesics,[1] as well as showing anti-addictive effects that may be useful in the treatment of alcoholism.[2][3]


  1. ^ Wells JL, Bartlett JL, Ananthan S, Bilsky EJ. In vivo pharmacological characterization of SoRI 9409, a nonpeptidic opioid mu-agonist/delta-antagonist that produces limited antinociceptive tolerance and attenuates morphine physical dependence. Journal of Pharmacology and Experimental Therapeutics. 2001 May;297(2):597-605. PMID 11303048
  2. ^ Nielsen CK, Simms JA, Pierson HB, Li R, Saini SK, Ananthan S, Bartlett SE. A novel delta opioid receptor antagonist, SoRI-9409, produces a selective and long-lasting decrease in ethanol consumption in heavy-drinking rats. Biological Psychiatry. 2008 Dec 1;64(11):974-81. PMID 18774553
  3. ^ Nielsen CK, Simms JA, Bito-Onon JJ, Li R, Ananthan S, Bartlett SE. The delta opioid receptor antagonist, SoRI-9409, decreases yohimbine stress-induced reinstatement of ethanol-seeking. Addiction Biology. 2011 Feb 11. doi:10.1111/j.1369-1600.2010.00295.x. PMID 21309957