SprD

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SprD
SprD SScons.png
Conserved secondary structure of SprD.
Identifiers
SymbolSprD
RfamRF01828
Other data
RNA typeGene
Domain(s)Staphylococcus aureus
PDB structuresPDBe

In molecular biology SprD (Small pathogenicity island RNA D) is a non-coding RNA expressed on pathogenicity islands in Staphylococcus aureus.[1] It was identified in silico along with a number of other sRNAs (SprA-G) through microarray analysis which were confirmed using a Northern blot.[2] SprD has been found to significantly contribute to causing disease in an animal model.[1]

Function[edit]

SprD is located between genes scn and chp in the innate immune evasion cluster (IEC) of the S. aureus genome. Its placement within this region was the first indication of a virulence-factor regulatory function.[1]

SprD binds with sbi (Staphylococcus aureus binder of IgG)[3] mRNA which encodes an immune evasion protein. It occludes the Shine-Dalgarno sequence and the initiation codon of sbi, forming a sbi mRNA-SprD duplex repressing the translation of the mRNA.[1]

sbi protein interferes with the host's innate immune response by binding Factor H, Complement component 3 and IgG.[3][4]

See also[edit]

References[edit]

  1. ^ a b c d Chabelskaya S, Gaillot O, Felden B (June 2010). "A Staphylococcus aureus small RNA is required for bacterial virulence and regulates the expression of an immune-evasion molecule". PLoS Pathog. 6 (6): e1000927. doi:10.1371/journal.ppat.1000927. PMC 2880579. PMID 20532214. Retrieved 2010-08-06.
  2. ^ Pichon C, Felden B (October 2005). "Small RNA genes expressed from Staphylococcus aureus genomic and pathogenicity islands with specific expression among pathogenic strains". Proc. Natl. Acad. Sci. U.S.A. 102 (40): 14249–54. doi:10.1073/pnas.0503838102. PMC 1242290. PMID 16183745. Retrieved 2010-08-06.
  3. ^ a b Haupt K, Reuter M, van den Elsen J, et al. (December 2008). "The Staphylococcus aureus protein Sbi acts as a complement inhibitor and forms a tripartite complex with host complement Factor H and C3b". PLoS Pathog. 4 (12): e1000250. doi:10.1371/journal.ppat.1000250. PMC 2602735. PMID 19112495. Retrieved 2010-08-09.
  4. ^ Zhang L, Jacobsson K, Vasi J, Lindberg M, Frykberg L (April 1998). "A second IgG-binding protein in Staphylococcus aureus". Microbiology. 144 (4): 985–91. doi:10.1099/00221287-144-4-985. PMID 9579072. Retrieved 2010-08-09.

Further reading[edit]

External links[edit]