|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||522.264 g/mol g·mol−1|
|3D model (JSmol)|
|(what is this?)|
Surinabant (SR147778) is a cannabinoid receptor type 1 antagonist developed by Sanofi-Aventis. It is being investigated as a potential treatment for nicotine addiction, to assist smoking cessation. It may also be developed as an anorectic drug to assist with weight loss, however there are already several CB1 antagonists or inverse agonists on the market or under development for this application, so surinabant is at present mainly being developed as an anti-smoking drug, with possible application in the treatment of other addictive disorders such as alcoholism. Other potential applications such as treatment of ADHD have also been proposed.
A dose ranging study was done for smoking cessation in 2012; it did not improve success rate, but reduced weight gain. Inhibition of THC effects on heart rate was seen at 20 mg and 60 mg but not 5 mg.
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- Gessa, GL; Serra, S; Vacca, G; Carai, MA; Colombo, G (2005). "Suppressing effect of the cannabinoid CB1 receptor antagonist, SR147778, on alcohol intake and motivational properties of alcohol in alcohol-preferring sP rats". Alcohol and Alcoholism. 40 (1): 46–53. doi:10.1093/alcalc/agh114. PMID 15582988.
- Lallemand, F; De Witte, P (Jul 2006). "SR147778, a CB1 cannabinoid receptor antagonist, suppresses ethanol preference in chronically alcoholized Wistar rats". Alcohol. 39 (3): 125–34. doi:10.1016/j.alcohol.2006.08.001. PMID 17127132.
- Louis, C; Terranova, JP; Decobert, M; Bizot, JC; Francon, D; Alonso, R; Cohen, C; Griebel, G (2005). "Surinabant, a new CB1 receptor antagonist, displays efficacy in animal models of attention deficit/hyperactivity disorder". Behavioural Pharmacology. 16: S42. doi:10.1097/00008877-200509001-00133.
- Tonstad, S; Aubin, HJ (Jul 2012). "Efficacy of a dose range of surinabant, a cannabinoid receptor blocker, for smoking cessation: a randomized controlled clinical trial". J Psychopharmacol. 26: 1003–9. doi:10.1177/0269881111431623. PMID 22219220.
- Klumpers, LE; Roy, C; Ferron, G; Turpault, S; Poitiers, F; Pinquier, JL; van Hasselt, JG; Zuurman, L; Erwich, FA; van Gerven, JM (Jul 2013). "Surinabant, a selective cannabinoid receptor type 1 antagonist, inhibits Δ9-tetrahydrocannabinol-induced central nervous system and heart rate effects in humans". Br J Clin Pharmacol. 76: 65–77. doi:10.1111/bcp.12071. PMC 3703229. PMID 23278647.