TAL2

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TAL2
Identifiers
AliasesTAL2, TAL bHLH transcription factor 2
External IDsOMIM: 186855 MGI: 99540 HomoloGene: 3954 GeneCards: TAL2
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for TAL2
Genomic location for TAL2
Band9q31.2Start105,662,457 bp[1]
End105,663,112 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005421

NM_009317

RefSeq (protein)

NP_005412

NP_033343

Location (UCSC)Chr 9: 105.66 – 105.66 MbChr 4: 53.78 – 53.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

T-cell acute lymphocytic leukemia 2, also known as TAL2, is a protein which in humans is encoded by the TAL2 gene.[5][6]

Function[edit]

TAL2 is a member of the basic helix-loop-helix family of transcription factors.[7]

Clinical significance[edit]

Tumor-specific alterations of the TAL2 gene occurs in some patients with T-cell acute lymphoblastic leukemia (T-ALL).[6][8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186051 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028417 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ "Entrez Gene: TAL2 T-cell acute lymphocytic leukemia 2".
  6. ^ a b Xia Y, Brown L, Yang CY, Tsan JT, Siciliano MJ, Espinosa R, Le Beau MM, Baer RJ (December 1991). "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11416–20. doi:10.1073/pnas.88.24.11416. PMC 53146. PMID 1763056.
  7. ^ Baer R (December 1993). "TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia". Semin. Cancer Biol. 4 (6): 341–7. PMID 8142619.
  8. ^ Marculescu R, Vanura K, Le T, Simon P, Jäger U, Nadel B (March 2003). "Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL". Nat. Genet. 33 (3): 342–4. doi:10.1038/ng1092. PMID 12567187.

Further reading[edit]