Testicular receptor 4

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Available structures
PDBOrtholog search: PDBe RCSB
AliasesNR2C2, TAK1, TR4, Testicular receptor 4, nuclear receptor subfamily 2 group C member 2
External IDsOMIM: 601426 MGI: 1352466 HomoloGene: 2475 GeneCards: NR2C2
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for NR2C2
Genomic location for NR2C2
Band3p25.1Start14,947,584 bp[1]
End15,053,600 bp[1]
RNA expression pattern
PBB GE NR2C2 206038 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 3: 14.95 – 15.05 MbChr 6: 92.09 – 92.17 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Testicular receptor 4 also known as NR2C2 (nuclear receptor subfamily 2, group C, member 2) is a protein that in humans is encoded by the NR2C2 gene.[5][6][7]

The testicular receptor 4 is a member of the nuclear receptor family of transcription factors.


Testicular receptor 4 has been shown to interact with

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177463 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005893 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ "Entrez Gene: NR2C2".
  6. ^ Chang C, Da Silva SL, Ideta R, Lee Y, Yeh S, Burbach JP (Jun 1994). "Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily". Proceedings of the National Academy of Sciences of the United States of America. 91 (13): 6040–4. doi:10.1073/pnas.91.13.6040. PMC 44133. PMID 8016112.
  7. ^ Yoshikawa T, DuPont BR, Leach RJ, Detera-Wadleigh SD (Jul 1996). "New variants of the human and rat nuclear hormone receptor, TR4: expression and chromosomal localization of the human gene". Genomics. 35 (2): 361–6. doi:10.1006/geno.1996.0368. PMID 8661150.
  8. ^ Lee YF, Shyr CR, Thin TH, Lin WJ, Chang C (Dec 1999). "Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily". Proceedings of the National Academy of Sciences of the United States of America. 96 (26): 14724–9. doi:10.1073/pnas.96.26.14724. PMC 24715. PMID 10611280.
  9. ^ Shyr CR, Hu YC, Kim E, Chang C (Apr 2002). "Modulation of estrogen receptor-mediated transactivation by orphan receptor TR4 in MCF-7 cells". The Journal of Biological Chemistry. 277 (17): 14622–8. doi:10.1074/jbc.M110051200. PMID 11844790.
  10. ^ Lin WJ, Li J, Lee YF, Yeh SD, Altuwaijri S, Ou JH, Chang C (Mar 2003). "Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4". The Journal of Biological Chemistry. 278 (11): 9353–60. doi:10.1074/jbc.M205944200. PMID 12522137.

Further reading[edit]

External links[edit]