From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Clinical data
Trade namesAvertin
SynonymsTribromoethyl alcohol
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.000.822 Edit this at Wikidata
Chemical and physical data
Molar mass282.757 g·mol−1
3D model (JSmol)
Melting point73–79 °C (163–174 °F) [1]
Boiling point92–93 °C (198–199 °F) at 10 mmHg[1]

Tribromoethanol is a sedative. It is used to anesthetize laboratory animals, particularly rodents, before surgery.[2] As a solution in tert-amyl alcohol, it has the brand name Avertin.[3] Tribromoethanol causes rapid and deep anesthesia followed by rapid and full postoperative recovery.[4]

Tribromoethanol was widely used as a general anesthetic in humans in the first half of the twentieth century.[5] Electrophysiology studies showed that tribromoethanol acts as a positive allosteric modulator of the inhibitory GABAA and glycine receptors, a mechanism similar to that seen with the related compound 2,2,2-trichloroethanol.[6] Bromal hydrate (2,2,2-tribromoethanol-1,1-diol), a compound also recognized to produce general anesthesia in animals, is metabolized to tribromoethanol.[7]

See also[edit]


  1. ^ a b "2,2,2-Tribromoethanol". Sigma-Aldrich.
  2. ^ "Tribromoethanol (Avertin)". Cold Spring Harbor Protocols. Cold Spring Harbor Laboratory.
  3. ^ "Guidelines for the Use of Tribromoethanol/Avertin Anesthesia" (PDF). National Cancer Institute.
  4. ^ "Tribromoethanol (Avertin) as an anaesthetic in mice" (PDF). Laboratory Animals. 33: 192–193. 1999.
  5. ^ G Edwards (1945). "Tribromethyl alcohol (avertin, bromethol), 1928-1945". Proceedings of the Royal Society of Medicine. 39: 71–76. PMID 21010258.
  6. ^ M.D. Krasowski & N.L. Harrison (2000). "The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations". British Journal of Pharmacology. 129 (4): 731–743. doi:10.1038/sj.bjp.0703087. PMC 1571881. PMID 10683198.
  7. ^ Lehman G and Knoefel PK (1938). Trichloroethanol, tribromoethanol, chloral hydrate, and bromal hydrate. J Pharmacol Exp Ther, 63: 453-465.