Tutin (toxin)

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Tutin structure.png
Clinical data
ATC code
  • none
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.236.780 Edit this at Wikidata
Chemical and physical data
Molar mass294.299 g/mol g·mol−1
3D model (JSmol)

Tutin is a poisonous plant derivative found in New Zealand tutu plants (several species in the genus Coriaria). It acts as a potent antagonist of the glycine receptor,[1] and has powerful convulsant effects.[2] It is used in scientific research into the glycine receptor. It is sometimes associated with outbreaks of toxic honey poisoning when bees feed on honeydew exudate from the sap-sucking passionvine hopper (Scolypopa australis) insect, when the vine hoppers have been feeding on the sap of tutu bushes. Toxic honey is a rare event and is more likely to occur when comb honey is eaten directly from a hive that has been harvesting honeydew from passionvine hoppers feeding on tutu plants.[3]


  1. ^ Fuentealba J, Guzmán L, Manríquez-Navarro P, Pérez C, Silva M, Becerra J, Aguayo LG. Inhibitory effects of tutin on glycine receptors in spinal neurons. European Journal of Pharmacology. 2007 Mar 15;559(1):61-4. PMID 17303114
  2. ^ Zhou H, Tang YH, Zheng Y. A new rat model of acute seizures induced by tutin. Brain Research. 2006 May 30;1092(1):207-13. PMID 16674929
  3. ^ Background on toxic honey. New Zealand Food Safety Authority.